A 10-Year Retrospective Analysis of Methyl Aminolevulinate Photodynamic Therapy Consultation at the Hospital de Braga
نویسندگان
چکیده
INTRODUCTION Photodynamic therapy (PDT) is a well-established treatment for actinic keratosis (AK), basal cell carcinoma (BCC), and Bowen's disease (BD). The object of this study was to describe the results of a retrospective analysis of patients treated with methyl aminolevulinate PDT (MAL-PDT) with red light, over the past decade at the Hospital de Braga (Braga, Portugal). METHODS This study is based on the retrospective analysis of the clinical records of patients treated with MAL-PDT from January 2003 to December 2013. RESULTS More than 550 patients with mean age of 72 years were treated with MAL-PDT. About two-thirds of these patients were female. In terms of diagnostics, 67% of the patient population were affected with AK, 27% presented with BCC, and 4% had BD. With an average follow-up of 5.5 years, 99.5% of the lesions had cleared. The recurrence of lesions occurred during the first year of follow-up, mostly large BCC localized on the trunk. CONCLUSION This study showed the excellence of MAL-PDT for treating AK, BCC, and BD, with a low recurrence rate.
منابع مشابه
Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinoma.
OBJECTIVE To compare 5-year lesion recurrence rates in primary nodular basal cell carcinoma treated with topical methyl aminolevulinate photodynamic therapy (PDT) or simple excision surgery. DESIGN Prospective, randomized, multicenter study. SETTING University hospital dermatology departments. PATIENTS A total of 97 patients, 50 with 53 lesions treated with methyl aminolevulinate PDT and ...
متن کاملOxygen saturation and perfusion changes during dermatological methyl- aminolevulinate photodynamic therapy Short title: Oxygen changes during photodynamic therapy
Jessica Tyrrell, Clare Thorn, Angela Shore, Sandra Campbell and Alison Curnow Clinical Photobiology, European Centre for Environment and Human Health, Peninsula Medical School, University of Exeter, Knowledge Spa, Royal Cornwall Hospital, Truro, Cornwall, TR1 3HD, UK. 2 Diabetes and Vascular Medicine, Peninsula NIHR Clinical Research Facility and Peninsula Medical School, University of Exeter, ...
متن کاملPhotodynamic therapy using topical methyl aminolevulinate vs surgery for nodular basal cell carcinoma: results of a multicenter randomized prospective trial.
BACKGROUND Photodynamic therapy (PDT) is increasingly used as a noninvasive treatment for nodular basal cell carcinoma (BCC), without a sound evidence base. OBJECTIVE To compare topical PDT, with the use of the sensitizer methyl aminolevulinate, and standard excision surgery in nodular BCC. DESIGN Prospective, randomized study. SETTING University dermatology departments. PATIENTS A tota...
متن کامل[Retrospective, descriptive, observational study of treatment of multiple actinic keratoses with topical methyl aminolevulinate and red light: results in clinical practice and correlation with fluorescence imaging].
BACKGROUND Actinic keratosis (AK) is one of the most common skin diseases seen in clinical practice. In the last 5 years, several studies assessing the efficacy of photodynamic therapy in the treatment of multiple AKs have been published. OBJECTIVE We aimed to assess the clinical outcomes of photodynamic therapy in patients with multiple AKs and the correlation of those outcomes with fluoresc...
متن کاملTopical photodynamic therapy for prevention of new skin lesions in renal transplant recipients.
Preclinical data suggest that topical methyl aminolevulinate photodynamic therapy may have potential in preventing new skin lesions in transplant recipients. An open intra-patient randomized study investigated the prevention potential of this treatment in 27 renal transplant patients with actinic keratoses and other skin lesions in two circular contralateral areas (5 cm diameter). The treatment...
متن کامل